Inhibitors of electron transport chain , oxidative phosphorylation , ionophores and uncouplers

Published by Darron Toy on



inhibitors of electron transport chain and this particular topic we are not only going to discuss about the inhibitors of electron transport chain we are also going to discuss about the inhibitors of the oxidative phosphorylation along with uncouple ups so here we have four subtopics and this first one is the inhibitors of electron transfer second one is the inhibitors of oxidative phosphorylation and next we will discuss about the uncouples of oxidative phosphorylation and at last we will talk about ionophores first let us talk about what are the inheritors of electron transfer at the complex 1 which means between NADH and coenzyme q an insecticide and a fish poison rotenone amobarbital which is a barbiturate and the PI reside in a all these three poisons inhibits the complex one next one is the inhibitors of the complex to the inhibitors of complex to the first one is TTFN a which means it is called as try an oil tri fluoro acetone which is a iron chelating agent and second one is the carboxyl and the third one is the malone 8 which was the competitive inhibitor of the facts and a dehydrogenase all these three inhibits complex 2 of electron transport chain and now between cytochrome B and cytochrome C that is the inhibitors of complex 3 the inhibitors of complex 3 or a and B which means a transfer anti mice in a and B stands for British anti leve site which is also called as dimercaprol these are the two inhibitors which inhibits the complex 3 and what about the inhibitors of the complex 4 which is also called as cytochrome C oxidase these inhibitors are carbon monoxide cyanide and sulfate and sodium azide all these four are the inhibitors of the complex four so if you see the overall list from complex one to complex for all these are the specific inhibitors of the electron transport chain from one to four now let us talk about the inhibitors of the oxidative phosphorylation which is the ATP synthase complex five so the first one is a tractor lo site is the important inhibitor of the oxidative phosphorylation so it is the one inhibits the transportation of ADP in as well as ATP out of the mitochondria if ADP is not coming in as well as if the ATP so form if it is not going out so we can say that increase the concentration of ATP inside the matrix blocks oxidative phosphorylation so attractive aside does the same and an important antibiotic called as oligo myzel so all ago Meissen completely blocks oxidation and phosphorylation which means oxidative phosphorylation by blocking the flow of protons through F not complex of the ATP synthase next one is venturi Siddim this venturi sidon inhibits F not complex and outerworld in there's a new one which inhibits the F one sub complex these are the inhibitors of oxidative phosphorylation next let us talk about what are the under Polar's of oxidative phosphorylation the important mechanism of action of these uncouple s are these are responsible for disruption of proton gradient across the inner mitochondrial membrane whenever we talk about uncouple us think about it disrupts electrochemical gradient across inner mitochondrial membrane these are two for dye nitro phenol FCC P which is also called as flourocarbon else I need fennel hydrazine and aspirin in high dose is also considered to be an important and coupler not only the uncouple s in the form of drugs and external agents we also have the physiological and couplers in the body an important one of the thermo Jenin calmodulin is also called as uncoupling protein one which is mainly located in the brown adipose tissue responsible for thermogenesis production of heat in the body and next one is called as thyroxine thyroid hormone and the long-chain free fatty acid also acts as a nun coupler along with unconjugated bilirubin all these are the physiological and couplers so after the end couplers let us go into the last concept of the inhibitors of etc' as well as oxidative phosphorylation which is ionophores iron ofourse our channel formers they create an ion channel which permits specific cations to penetrate membranes so whenever these specific cations penetrate these membranes it dissipates proton gradient so light uncovers but mechanism is different but these are also disrupting the so paiting the proton gradient so these are Valley no Meissen gramicidin and nagar ism so all these three are the important ion of force by this we completed the topic called as inhibitors of electron transport chain as well as the inhibitors of oxidative phosphorylation and uncovers and ionophores


6 Comments

Darshita Soni · May 15, 2019 at 9:08 am

Thank u sir…. Ur tone n explaintion is really too good…. Tq🙏

Sakshyam Adhikari · May 15, 2019 at 9:08 am

Thank you sir ❤❤

Kaiser Rashid · May 15, 2019 at 9:08 am

Thank you so much sir 🙏🏻

utkarsh dubey · May 15, 2019 at 9:08 am

You are a lifesaver…..Huge Respect from Medical Fraternity

srinivasa rao sirasapalli · May 15, 2019 at 9:08 am

so cleary explained.thank you sir

Sharon Glenn · May 15, 2019 at 9:08 am

Very helpful

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